Darwin the Guinea Pig (voice)

Sam Rockwell

Acting

Hurley the Guinea Pig (voice)

Jon Favreau

Acting

Blaster the Guinea Pig (voice)

Tracy Morgan

Acting

Juarez the Guinea Pig (voice)

Penélope Cruz

Acting

Speckles the Mole (voice)

Nicolas Cage

Acting

Mooch the Fly (voice)

Dee Bradley Baker

Acting

Leonard Saber

Bill Nighy

Acting

Kip Killian

Will Arnett

Acting

Ben

Zach Galifianakis

Acting

Marcie

Kelli Garner

Acting

Bucky the Hamster (voice)

Steve Buscemi

Acting

Jared the Skunk (voice)

Jared Lavette

Acting

Micah the Fox (voice)

Micah Lavette

Acting

Rosalita

Niecy Nash-Betts

Acting

Grandpa Goodman

Loudon Wainwright III

Acting

Connor

Tyler Patrick Jones

Acting

Penny

Piper Mackenzie Harris

Acting

NSA Director

Chris Ellis

Acting

Carter

Gabriel Casseus

Acting

Terrell

Justin Mentell

Acting

Agent

Troy Robinson

Acting

Agent

Travis Davis

Acting

Agent

Corey Michael Eubanks

Acting

Saber's Assistant

Mini Anden

Acting

Skateboarder #1 (as Cameron Engels)

Camaron Engels

Acting

Agent

Steve Kelso

Crew

Mice (voice)

Max Favreau

Acting

Agent

James Huang

Acting

Agent Trigstad

Jack Conley

Acting