Susan Murphy / Ginormica (voice)

Reese Witherspoon

Acting

B.O.B. (voice)

Seth Rogen

Acting

Dr. Cockroach Ph.D. (voice)

Hugh Laurie

Acting

Gallaxhar (voice)

Rainn Wilson

Acting

The Missing Link (voice)

Will Arnett

Acting

General W.R. Monger (voice)

Kiefer Sutherland

Acting

Derek Dietl (voice)

Paul Rudd

Acting

President Hathaway (voice)

Stephen Colbert

Acting

Wendy Murphy (voice)

Julie White

Acting

Carl Murphy (voice)

Jeffrey Tambor

Acting

Computer (voice)

Amy Poehler

Acting

News Reporter (voice)

Ed Helms

Acting

Katie (voice)

Renée Zellweger

Acting

Private Bullhorn / Helicopter Pilot / Advisor Ortega (voice)

Sean Bishop

Acting

Commander / Advisor Smith (voice)

Rich Dietl

Editing

Secret Service Man #1 / Lieutenant (voice)

Rob Letterman

Directing

Wilson (voice)

Tom McGrath

Acting

Advisor Cole / Army Commander Jones (voice)

Chris Miller

Acting

Advisor Wedgie (voice)

Mike Mitchell

Directing

Technician Jerry (voice)

Kent Osborne

Writing

Advisor Ouaou / Mrs. Ronson / Female Advisor #2 / Panicked Guest (voice)

Latifa Ouaou

Acting

Soldier #4 / Pilot / Soldier #3 / News Technician (voice)

Geoffrey Pomeroy

Acting

Soldier #1 / Advisor Jackson (voice)

David P. Smith

Acting

Bridesmaid Candy (voice)

Lisa Stewart

Production

Advisor Hawk / Advisor Dither / Minister / Secret Service Man #2 / Mama Dietl (voice)

Conrad Vernon

Acting

Cuthbert (voice)

John Krasinski

Acting

Technician Bee (voice)

Stephen Kearin

Acting