Dr. Ira Kane

David Duchovny

Acting

Dr. Allison Reed, CDC

Julianne Moore

Acting

Prof. Harry Phineas Block

Orlando Jones

Acting

Wayne Grey

Seann William Scott

Acting

General Russell Woodman

Ted Levine

Acting

Colonel Flemming

Ty Burrell

Acting

Deke

Ethan Suplee

Acting

Danny

Michael Bower

Acting

Governor Lewis

Dan Aykroyd

Acting

Cartwright

Gregory Itzin

Acting

Officer Johnson

Pat Kilbane

Acting

Denise

Sarah Silverman

Acting

Carla

Michelle Wolff

Acting

Nadine

Katharine Towne

Acting

Jill Mason

Stephanie Hodge

Acting

Student

John Cho

Acting

Judge Guilder

Steven Gilborn

Acting

Dr. Paulson

Wayne Duvall

Acting

Officer Drake

Kyle Gass

Acting

Tommy

Jerry Trainor

Acting

Clare

Jennifer Savidge

Acting

Nurse Tate

Wendy Braun

Acting

Sheriff Long

Michael Chapman

Camera

Customer

Mary Pat Gleason

Acting

Road Worker

Andrew Bowen

Acting

Student

Chris Wylde

Acting

Lead Primate Creature (uncredited)

Tom Woodruff Jr.

Acting

Lt. Cryer

Ashley Clark

Acting