Ranger Margaret (voice)

Whoopi Goldberg

Acting

Ranger Frank (voice)

David Spade

Acting

Tommy Pickles (voice)

E. G. Daily

Acting

Dilan "Dil" Pickles (voice)

Tara Strong

Acting

Chuckie Finster (voice)

Christine Cavanaugh

Acting

Phil / Lil / Betty DeVille (voices)

Kath Soucie

Acting

Angelica Pickles (voice)

Cheryl Chase

Acting

Rex Pester (voice)

Tim Curry

Acting

Stuart 'Stu' Pickles (voice)

Jack Riley

Acting

Reptar Wagon (voice)

Busta Rhymes

Acting

Charles 'Chaz' Finster Sr. / Grandpa Boris Kropotkin / Drew Pickles (voice)

Michael Bell

Acting

Grandpa Lou Pickles (voice)

Joe Alaskey

Acting

Howard DeVille / Igor (voice)

Phil Proctor

Acting

Susie Carmichael (voice)

Cree Summer

Acting

Charlotte Pickles (voice)

Tress MacNeille

Acting

Didi Pickles / Minka Kropotkin (voice)

Melanie Chartoff

Acting

Lucy Carmichael (voice)

Hattie Winston

Acting

Aunt Miriam (voice)

Andrea Martin

Acting

Dr. Lipschitz (voice)

Tony Jay

Acting

Serge (voice)

Abraham Benrubi

Acting

TV Announcer (voice)

Gregg Berger

Acting

United Express Driver (voice)

Charlie Adler

Acting

Female Guest (voice)

Mary Gross

Acting

Nurse (voice)

Edie McClurg

Acting

Air Crewman (voice)

Roger Clinton, Jr.

Acting

Lt. Klavin (voice)

Margaret Cho

Acting

Newborn Baby (singing voice)

Iggy Pop

Acting

Newborn Baby (singing voice)

Louis Fresse

Acting

Newborn Baby (singing voice)

Lisa Loeb

Acting

Newborn Baby (singing voice)

Lenny Kravitz

Acting

Newborn Baby (singing voice)

Dawn Robinson

Acting

Newborn Baby (singing voice)

Lou Rawls

Acting

Newborn Baby (singing voice)

Kate Pierson

Acting

Newborn Baby (singing voice)

Cindy Wilson

Acting

Newborn Baby (singing voice)

Gordon Gano

Acting

Newborn Baby (singing voice)

Laurie Anderson

Acting

Newborn Baby (singing voice)

Malik Isaac Taylor

Acting

Newborn Baby (singing voice)

Fred Schneider

Acting

Newborn Baby (singing voice)

Jakob Dylan

Acting

Newborn Baby (singing voice)

Patti Smith

Acting

Newborn Baby (singing voice)

Beck

Acting

Reporter (voice)

Steve Zirnkilton

Acting

Spike / Monkeys / Scar Snout (voice) (uncredited)

Frank Welker

Acting

Newborn Baby (Singing Voice)

Phife Dawg

Acting