Miles Morales (voice)

Shameik Moore

Acting

Gwen Stacy (voice)

Hailee Steinfeld

Acting

Jeff Morales (voice)

Brian Tyree Henry

Acting

Rio Morales (voice)

Luna Lauren Vélez

Acting

Miguel O'Hara (voice)

Oscar Isaac

Acting

Peter B. Parker (voice)

Jake Johnson

Acting

Spot (voice)

Jason Schwartzman

Acting

Jessica Drew (voice)

Issa Rae

Acting

Hobie Brown (voice)

Daniel Kaluuya

Acting

Spider-Man Noir (voice)

Nicolas Cage

Acting

Spider-Ham (voice)

John Mulaney

Acting

Peni Parker (voice)

Kimiko Glenn

Acting

Margo Kess (voice)

Amandla Stenberg

Acting

Pavitr Prabhakar (voice)

Karan Soni

Acting

Uncle Aaron (voice)

Mahershala Ali

Acting

Miles G. Morales (voice)

Jharrel Jerome

Acting

LYLA (voice)

Greta Lee

Acting

Ben Reilly (voice)

Andy Samberg

Acting

George Stacy (voice)

Shea Whigham

Acting

Tombstone (voice)

Marvin Jones III

Acting