Dr. Heywood Floyd

Roy Scheider

Acting

Dr. Walter Curnow

John Lithgow

Acting

Tanya Kirbuk

Helen Mirren

Acting

Dr. R. Chandra

Bob Balaban

Acting

Dr. David Bowman

Keir Dullea

Acting

HAL 9000 (voice)

Douglas Rain

Acting

Caroline Floyd

Madolyn Smith Osborne

Acting

Dr. Vladimir Rudenko

Савелий Крамаров

Acting

Christopher Floyd

Taliesin Jaffe

Acting

Victor Milson

James McEachin

Acting

Betty Fernandez

Mary Jo Deschanel

Acting

Maxim Brailovsky

Ilya Baskin

Acting

Dimitri Moisevitch

Dana Elcar

Acting

Dr. Vasili Orlov

Oleg Rudnik

Acting

Irina Yakunina

Natasha Shneider

Acting

Yuri Svetlanov

Vladimir Skomarovsky

Acting

Nikolaj Ternovsky

Victor Steinbach

Acting

SAL 9000 (voice)

Candice Bergen

Acting

Commercial Announcer

Gene McGarr

Acting

Jessie Bowman

Herta Ware

Acting

Alexander Kovalev

Jan Tříska

Acting

Anchorman on TV

Larry Carroll

Acting

Nurse

Cheryl Carter

Acting

Hospital Neurosurgeon

Ron Recasner

Acting

Dr. Hirsch

Robert Lesser

Acting

Commercial Announcer

Delana Michaels

Acting

Man on Park Bench (uncredited)

Arthur C. Clarke

Writing