Peter Highman

Robert Downey Jr.

Acting

Ethan Tremblay

Zach Galifianakis

Acting

Sarah Highman

Michelle Monaghan

Acting

Darryl

Jamie Foxx

Acting

Heidi

Juliette Lewis

Acting

Lonnie

Danny McBride

Acting

Airport Screener

RZA

Sound

TSA Agent

Matt Walsh

Acting

Limo Driver

Brody Stevens

Acting

Patrick

Jakob Ulrich

Acting

Alex

Naiia Ulrich

Acting

Barry

Todd Phillips

Directing

Carl

Bobby Tisdale

Acting

Airport X-Ray

Sharon Conley

Acting

Flight Attendant

Nathalie Fay

Acting

Flight Attendant

Emily Wagner

Acting

Air Marshall

Steven M. Gagnon

Acting

Border Guard

Paul Renteria

Acting

Federali Agent

Marco Rodríguez

Acting

Sarah's Mom

Mimi Kennedy

Acting

New Mother

Tymberlee Hill

Acting

New Father

Keegan-Michael Key

Acting

Dr. Greene

Aaron Lustig

Acting

Charlie Harper

Charlie Sheen

Acting

Alan Harper

Jon Cryer

Acting

Airport Passenger (uncredited)

Haji Abdullah

Acting

TSA Agent (uncredited)

Jeremy Ambler

Acting

Airport Pedestrian (uncredited)

Madeline Brumby

Acting

Private Johnson (uncredited)

Joseph Harold

Acting

Airport Security Agent (uncredited)

Sarah Reagin Clemmensen

Crew

Elderly Airport Passenger (uncredited)

Connie Sawyer

Acting