The Dean (segment "Happy Birthday")

John Goodman

Acting

Hannah (segment "Happy Birthday")

Sydney Tamiia Poitier

Acting

Bag Lady (segment "Happy Birthday")

Beverly D'Angelo

Acting

Attorney Bum (segment "Happy Birthday")

Christopher Lloyd

Acting

Barney (segment "Happy Birthday")

David Hyde Pierce

Acting

Monica (segment "Happy Birthday")

Caroline Rhea

Acting

Sally (segment "Happy Birthday")

Jenica Bergere

Acting

Security Guard (segment "Happy Birthday")

Ken Hudson Campbell

Acting

Donald (segment "Happy Birthday")

Roman Danylo

Acting

May Lee Ha (segment "Happy Birthday")

Kimiko Gelman

Acting

Nurse (segment "Happy Birthday")

Jean Kasem

Acting

Policeman (segment "Happy Birthday")

Taylor Negron

Acting

Chute Boy (segment "Happy Birthday")

Travis Wester

Acting

Man in Elevator (segment "Happy Birthday")

Dondré Whitfield

Acting

Dean's Secretary (segment "Happy Birthday")

Marissa Jaret Winokur

Acting

(segment "The Other Side")

Bruce Davison

Acting

Dr. Maas (segment "The Other Side")

Anthony LaPaglia

Acting

Anna (segment "The Other Side")

Karen Sillas

Acting

Lisa (segment "Reaching Normal")

Andie MacDowell

Acting

Kenneth (segment "Reaching Normal")

Paul Rudd

Acting

Sarah (segment "Reaching Normal")

Joey Lauren Adams

Acting

Frank (segment "Reaching Normal")

Alan Rosenberg

Acting

Dr. Mensley (segment "Reaching Normal")

Joel Grey

Acting

Charlie's Wife (wraparound segments)

Jolene Blalock

Acting

Charlie (wraparound segments)

Scott Lowell

Acting

Tom (wraparound segments)

Stephen Tobolowsky

Acting

Lucy (wraparound segments)

Kathleen Wilhoite

Acting

Operator (segment "Reaching Normal") (uncredited)

Ellen DeGeneres

Acting

Distinguished Woman (segment "Happy Birthday") (uncredited)

Helen Mirren

Acting