George Beard (voice)

Kevin Hart

Acting

Harold Hutchins (voice)

Thomas Middleditch

Acting

Mr. Krupp / Captain Underpants (voice)

Ed Helms

Acting

Professor Poopypants (voice)

Nick Kroll

Acting

Melvin (voice)

Jordan Peele

Acting

Edith (voice)

Kristen Schaal

Acting

Ms. Ribble (voice)

DeeDee Rescher

Acting

Mr. Rected (voice)

Brian Posehn

Acting

Tommy (voice)

David Soren

Acting

Mr. Fyde (voice)

Mel Rodriguez

Acting

Ms. Dayken (voice)

Susan Fitzker

Acting

George's Mom (voice)

Lynnanne Zager

Acting

Sad Girl (voice)

Tiffany Lauren Bennicke

Acting

Mime (voice)

James Ryan

Editing

Officer McPiggly (voice)

Leslie David Baker

Acting

Goodie Two-Shoes Girl (voice)

Sugar Lyn Beard

Acting

Nobel Moderator (voice)

Lesley Nicol

Acting

Nobel Audience Member (voice)

Chris Miller

Acting

Balloon Girl (voice)

Coco Soren

Acting