Igor (voice)

John Cusack

Acting

Dr. Holzwurm (voice)

Myleene Klass

Acting

Dr. Holzwurm's Igor (voice)

Robin Walsh

Acting

Dr. Herzschlag (voice)

Matt McKenna

Acting

Dr. Glickenstein (voice)

John Cleese

Acting

Scamper (voice)

Steve Buscemi

Acting

Brain (voice)

Sean Hayes

Acting

Dr. Schadenfreude (voice)

Eddie Izzard

Acting

King Malbert (voice)

Jay Leno

Acting

Jaclyn / Heidi (voice)

Jennifer Coolidge

Acting

Eva (voice)

Molly Shannon

Acting

Himself

James Lipton

Acting

Dr. Schadenfreude's Igor (voice)

Christian Slater

Acting

Carl Cristall (voice)

Arsenio Hall

Acting

Announcer / Royal Guard #2 (voice)

Jess Harnell

Acting

Blind Woman / Killiseum Fan #1 (voice)

Zoë Bright

Acting

Blind Orphan #1 (voice)

Sophia Eraklis

Acting

Blind Orphan #2 / Blind Orphan #4 (voice)

A. Cheron Hall

Acting

Blind Orphan #3 (voice)

Alexander Leondis

Acting

Blind Orphan #6 (voice)

Michael Leondis

Acting

Blind Orphan #7 (voice)

Nicole Leondis

Acting

Blind Orphan #5 (voice)

Juliana Leondis

Acting

Blind Orphan #8 (voice)

Robin Tisserand

Acting

Buzz Offmann (voice)

Paul Vogt

Acting

Animals' vocal effects (voice) (uncredited)

Frank Welker

Acting