Osmosis Jones (voice)

Chris Rock

Acting

Thrax (voice)

Laurence Fishburne

Acting

Drix (voice)

David Hyde Pierce

Acting

Leah (voice)

Brandy Norwood

Acting

Frank Detorre

Bill Murray

Acting

Mrs. Boyd

Molly Shannon

Acting

Mayor Phlegmming (voice)

William Shatner

Acting

Tom Colonic (voice)

Ron Howard

Directing

(voice)

Sherry Lynn

Acting

Additional Character Voice (voice)

Mickie McGowan

Acting

Bob

Chris Elliott

Acting

Shane Detorre

Elena Franklin

Acting

Kidney Rock

Kid Rock

Acting

Kidney Rock (voice)

Uncle Kracker

Acting

Additional Character Voices (voice)

Carlos Alazraqui

Acting

Additional Character Voices (voice)

Rodger Bumpass

Acting

Additional Character Voices (voice)

Richard Steven Horvitz

Acting

Additional Character Voices (voice)

Danny Mann

Acting

Additional Character Voices (voice)

Mickie McGowan

Acting

Additional Character Voices (voice)

Jonathan Adams

Acting