James 'Jimmy' Isaac Neutron (voice)

Debi Derryberry

Acting

Judy Neutron / VOX (voice)

Megan Cavanagh

Acting

Hugh Neutron / Pilot / Arena Guard (voice)

Mark DeCarlo

Acting

Sheen Estevez (voice)

Jeffrey Garcia

Acting

King Goobot V (voice)

Patrick Stewart

Acting

Ooblar (voice)

Martin Short

Acting

Goddard / Poultra (voice)

Frank Welker

Acting

Carl Wheezer / Mr. and Mrs. Wheezer / Kid in Classroom (voice)

Rob Paulsen

Acting

Cindy Vortex (voice)

Carolyn Lawrence

Acting

Libby Folfax (voice)

Crystal Scales

Acting

Nick Dean / Britney / PJ (voice)

Candi Milo

Acting

Yokian Guard / Gus (voice)

David L. Lander

Acting

Mr. Estevez (voice)

Carlos Alazraqui

Acting

Ultra Lord / Mission Control / General Bob (voice)

Jim Cummings

Acting

Bobby / Kid / Control Yokian (voice)

Keith Alcorn

Directing

Zachary / Reporter / Angie / Libby's Mom (voice)

Kimberly Brooks

Acting

Ms. Winfred Fowl (voice)

Andrea Martin

Acting

Bobby's Twin Brother (voice) / Butch (voice) / Jailbreak Cop (voice) / Old Man Johnson (voice) / Robobarber (voice) / Flurp Announcer (voice) / Yokian Officer (voice) / Anchor Boy (voice) / Guard (voice)

Billy West

Acting

Yokian Newscaster #2 (voice)

Mary Hart

Acting

Yokian Newscaster #1 (voice)

Bob Goen

Acting

Norad Officer (voice)

Dee Bradley Baker

Acting

Hostess (voice)

Laraine Newman

Acting

Octapuke Kid / Guard / Bennie (voice)

John A. Davis

Production

Guard (voice)

Paul Greenberg

Acting

Yokian Incubator Operator (voice)

Mark Menza

Sound

Little Girl / Camera Person (voice)

Jeannie Elias

Acting

Chris (voice)

Michael Hagiwara

Acting

Digital Voice (voice)

Richard Allen

Acting

Screamer (voice)

Brian Capshaw

Crew

Screamer (voice)

Cheryl Ray

Visual Effects

Hyperactive Kid / Arena Yokian (voice)

Matthew Russell

Visual Effects