Professor Brody

Jeff Goldblum

Acting

Mrs. Brody

Elizabeth Perkins

Acting

Scotty Brody

Alexander Pollock

Acting

Sophie the Castle Maid

Miriam Margolyes

Acting

Lou the Beagle (voice)

Tobey Maguire

Acting

Butch (voice)

Alec Baldwin

Acting

Mr. Tinkles (voice)

Sean Hayes

Acting

Ivy (voice)

Susan Sarandon

Acting

Peek (voice)

Joe Pantoliano

Acting

Sam (voice)

Michael Clarke Duncan

Acting

Calico (voice)

Jon Lovitz

Acting

The Mastiff (voice)

Charlton Heston

Acting

Russian Blue (voice)

Glenn Ficarra

Writing

Ninja Cat #1 (voice)

Billy West

Acting

Ginger Kitten (voice)

John Michael Higgins

Acting

Puppy in Barn (voice)

Richard Steven Horvitz

Acting

Buddy (voice)

Frank Welker

Acting

The Farmer

Frank C. Turner

Acting

Pie Mom (as Kirsten Robek)

Lauren K. Robek

Acting

Guard at Gate

Mar Andersons

Acting

Factory Receptionist

Gillian Barber

Acting

Sophie's Sister

Carol Ann Susi

Acting

Sophie's Sister

Randi Kaplan

Acting

Sophie's Sister

Mary Bogue

Acting

Mason Employee

Alvin Sanders

Acting

Mason Employee

Mark Schooley

Acting

Worker

Lou Bollo

Crew

Worker

Scott Nicholson

Crew

Worker

Trish Schill

Crew

Wife Passenger

Babe Dolan

Acting

Truck Driver (as Reginald Glass)

Reg Glass

Crew

Truck Driver

Charles Andre

Acting

Nurse

Peggy Logan

Acting

Jogger

Alicia Michelle

Acting

Yorkie Dog Owner

Pamela Perry

Acting

Doberman Drill Sergeant (voice)

Victor Wilson

Acting

Collie at HQ (voice)

Salome Jens

Acting

Ninja Cat (voice)

Danny Mann

Acting

Ninja Cat (voice)

Billy West

Acting

Wolf Blitzer (voice)

Paul Pape

Acting

Mr. Mason

Myron Natwick

Acting

Mrs. Calvert

Doris Chillcott

Acting

Additional Performances (puppeteer)

Frank Meschkuleit

Acting